The TRANSFORM-2 study found patients receiving Spravato were 70% more likely to achieve remission compared to placebo
Spravato Treatment in Spring, TX: The First FDA-Approved Nasal Spray for Treatment-Resistant Depression — Now Available Near You
The first genuinely new class of antidepressant in over thirty years, available at a REMS-certified clinic serving Spring and north Houston. Led by Dr. Ho, board-certified anesthesiologist and former pediatrician. Three convenient locations open 6am–9pm, seven days a week.
Relief Awaits Near Spring
Depression that doesn’t respond to antidepressants isn’t rare — it affects roughly one in three people who seek treatment. If you’ve tried two or more medications without meaningful improvement, you’ve joined a population of millions who’ve done everything their doctors asked and still haven’t found relief. The frustration of that experience — the waiting, the dose changes, the hope followed by disappointment — is something no one outside of it fully understands.
Spravato treatment in Spring offers a fundamentally different path. Unlike every conventional antidepressant on the market, Spravato received FDA approval specifically for the patients those medications failed — people with treatment-resistant depression and those with major depressive disorder accompanied by suicidal thoughts or behaviors. It’s not another variation on the same pharmacological theme. It’s the first genuinely new mechanism of action for depression in more than three decades.
At Catalyst Health & Wellness, we’re a fully REMS-certified Spravato provider serving Spring and the surrounding north Houston communities. Our approach pairs rigorous medical oversight with authentic human warmth — because effective treatment requires both clinical precision and the kind of care that makes you feel safe enough to trust the process. With three locations across Houston, scheduling flexibility that respects your life, and a dedicated team that navigates the insurance process on your behalf, we’re here to help you access a treatment that was built for exactly your situation.
What is Spravato Therapy?
Spravato (esketamine) isn’t an incremental improvement on existing antidepressants. It’s a categorical departure from them. Approved by the FDA in 2019 for treatment-resistant depression and expanded in 2020 to include major depressive disorder with suicidal thoughts or behaviors, Spravato is the first and only nasal spray designed specifically for patients whose depression hasn’t yielded to conventional medication.
The distinction isn’t just regulatory — it’s biological. Every standard antidepressant works by adjusting serotonin, norepinephrine, or dopamine levels in the brain. Spravato targets the glutamate system instead, acting on NMDA receptors to promote neuroplasticity — your brain’s capacity to form new neural connections. Imagine the neural pathways that chronic depression has worn thin or severed entirely. Spravato helps your brain rebuild them, breaking free from the entrenched patterns that keep you locked in depression even when you’re doing everything right.
Research consistently demonstrates powerful results:
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Conditions We Treat with Spravato Treatment in Spring
Spravato has received FDA approval for specific conditions, ensuring you receive a treatment with proven safety and efficacy. At Catalyst Health & Wellness, we offer Spravato for:
Your Spravato Therapy Journey at Catalyst Health & Wellness
We've designed every step of your experience to be comfortable, supportive, and focused on your unique needs. Here's what you can expect when you choose Catalyst for Spravato treatment in Spring.
Step 1: Free Phone Consultation
Call (713) 772-5315 and speak directly with someone who understands treatment-resistant depression — not a scheduling coordinator reading from a script. We’ll discuss your symptoms, your medication history, and whether Spravato is a strong fit for your clinical picture. No referral required. No charge. No pressure.
Step 2: Insurance Verification & Prior Authorization
This is where Catalyst’s team earns its keep. Spravato is FDA-approved and frequently covered by insurance, but coverage requires prior authorization. Our experienced staff handles the entire process — verifying your benefits, submitting prior authorization paperwork, communicating with your insurance company, and keeping you informed at every step. We work to maximize your coverage and minimize your out-of-pocket cost so you can focus on getting better instead of fighting paperwork.
Step 3: Before Your First Visit
Once insurance authorization is secured, we’ll schedule your first session and send preparation instructions:
- Continue taking your current oral antidepressant as prescribed — Spravato works alongside it, not as a replacement
- Don’t eat for at least 2 hours before treatment (light snack is fine before that)
- Don’t drink liquids for at least 30 minutes before treatment
- Arrange a ride home — you cannot drive until the day after treatment
- If you use a nasal corticosteroid or decongestant spray, use it at least 1 hour before your Spravato session
- Wear comfortable clothing and plan for approximately 2.5 to 3 hours total at the clinic
Step 4: Day of Treatment
When you arrive at the clinic:
- We’ll check your blood pressure and review how you’re feeling
- You’ll be escorted to a private treatment room with a comfortable reclining chair, adjustable lighting, noise-cancelling headphones, calming music, an eye mask, and a warm blanket
- Your treatment team will walk you through the self-administration process — you’ll spray the medication into your own nose under our direct supervision
- Dr. Ho or a clinical team member remains accessible throughout
Step 5: Your Treatment Session
Spravato administration is straightforward. You’ll use the nasal spray device to deliver the medication — one spray in each nostril, rest five minutes, then repeat. The entire administration takes approximately 10-15 minutes. Dosing starts at 56mg and may be adjusted to 84mg based on your response and tolerability.
During and after administration, you may experience:
- A sense of calm or mild disconnection
- Temporary dizziness or lightheadedness
- Changes in perception — some patients describe mild visual or sensory shifts
- A temporary increase in blood pressure (monitored throughout)
These effects are expected, manageable, and typically resolve within 1-2 hours. Most patients describe the experience as surprisingly peaceful.
Step 6: Recovery & Aftercare
After administration, you’ll remain in your private room for a mandatory 2-hour observation period. This isn’t just a regulatory requirement — it’s built into your care:
- Your vital signs are monitored at regular intervals
- You’ll rest comfortably while the acute effects subside
- Many patients use this time to rest, listen to music, or simply enjoy a rare stretch of uninterrupted quiet
- By the end of the observation period, most patients feel clear-headed and grounded
Before you leave, we’ll ensure you’re feeling stable and ready. Remember: you cannot drive until the next day after a restful night’s sleep. Have your ride arranged in advance.
Our team will follow up by phone that evening or the next morning to check on how you’re doing.
Step 7: Treatment Schedule & Maintenance
Spravato follows a structured dosing schedule designed to build and sustain your improvement:
- Weeks 1-4 (Induction): Treatment twice per week
- Weeks 5-8 (Optimization): Treatment once per week
- Week 9 onward (Maintenance): Treatment once weekly or every two weeks, based on your individual response
The frequency tapers as your brain consolidates the neural changes Spravato promotes. At every appointment, we reassess your response and adjust the plan accordingly. The goal is always to find the minimum effective frequency that keeps your depression in sustained remission.
The Science Behind Spravato for Treatment-Resistant Depression
Spravato’s clinical credibility isn’t built on preliminary results or small pilot studies. It rests on large-scale, randomized, controlled trials that met the FDA’s rigorous standards for approval.
The TRANSFORM-2 study, published in the American Journal of Psychiatry, demonstrated that patients receiving flexibly-dosed Spravato plus an oral antidepressant experienced significantly greater improvement in depression symptoms compared to placebo plus an oral antidepressant. Patients were 70% more likely to achieve remission, with benefits often beginning within 24 hours.
The SUSTAIN-1 trial, published in JAMA Psychiatry, showed that continued Spravato treatment significantly reduced the risk of relapse in patients who had achieved stable remission or response. Patients who discontinued Spravato were much more likely to relapse compared to those who continued maintenance treatment — confirming that ongoing treatment preserves the gains Spravato produces.
Spring — a growing community of over 60,000 residents along the I-45 corridor in northern Harris County — is an area where families approach healthcare decisions with the seriousness they deserve. These trials provide the evidence base that standard warrants.
Key research findings:
- Spravato promotes rapid synapse formation in mood-regulating brain regions
- Effects often begin within hours, not the weeks required by traditional antidepressants
- Helps restore neural connections damaged by chronic stress and depression
- Represents the first genuinely new mechanism for depression treatment in over 30 years
Why Choose Catalyst Health & Wellness for Spravato Therapy
01
REMS-Certified Provider
Spravato is only available through the FDA's Risk Evaluation and Mitigation Strategy (REMS) program — a framework ensuring that this powerful medication is delivered with the highest safety standards. Catalyst Health & Wellness is fully REMS-certified across all three Houston locations, meaning your treatment meets every federal safety requirement from administration through monitoring.
02
Led by Dr. Ho – Expert Medical Care
Dr. Ho brings a rare combination of expertise to your Spravato treatment. As a board-certified anesthesiologist, he has extensive training with esketamine and deep fluency in patient safety monitoring, hemodynamic management, and pharmacological precision. His background as a former pediatrician adds something equally important: a communication style built on patience, transparency, and genuine warmth. That combination means you receive treatment that’s both medically rigorous and deeply human.
03
Insurance Navigation Support
Unlike many innovative mental health treatments, Spravato is often covered by insurance — a significant advantage for patients who need this treatment but face financial barriers. Our experienced team handles the entire insurance process from start to finish: benefits verification, prior authorization submissions, appeals when necessary, and ongoing communication with your insurance company to maximize your coverage and minimize your out-of-pocket costs. You focus on getting better. We handle the paperwork.
04
Whole-Person Approach
We don’t reduce you to a diagnosis. From your first phone call through every maintenance session, we focus on understanding you as a complete person — your history, your daily realities, your goals, and the specific outcomes that would constitute meaningful change in your life.
What this means for you:
- Treatment plans personalized to your unique clinical history
- Consideration of your current symptoms and individual goals
- Ongoing adjustments based on what works best for you
- Care that evolves as you progress through treatment
05
Extended Hours & Flexible Scheduling
Spravato treatments require 2+ hours in our clinic, which can be difficult to fit into a traditional work schedule. That’s why all three Catalyst locations are open from 6am to 9pm, seven days a week. Whether you need an early morning appointment before the workday begins, an evening session after your responsibilities are handled, or weekend treatment when weekdays won’t cooperate, we accommodate your schedule — not the other way around.
06
Comprehensive Treatment Options
Spravato is a powerful tool, but it’s not the only one. When your clinical picture benefits from a multi-modal approach, Catalyst offers complementary evidence-based treatments under the same roof:
Ketamine Therapy
Broader applications including anxiety, PTSD, chronic pain, OCD, and bipolar depression
TMS Therapy
Non-invasive magnetic brain stimulation for depression and OCD
Stellate Ganglion Block
Targeted nerve block treatment for PTSD and anxiety
Our goal is to find the right combination of treatments for your unique situation — not to fit you into a one-size-fits-all protocol.
07
Safe, Comfortable Environment
Every detail of our treatment rooms has been designed with your comfort in mind. You’ll relax in a comfortable, reclining chair in a private room with adjustable lighting. We provide noise-cancelling headphones, calming music, eye masks, and warm blankets. Our medical team is always nearby, monitoring your vital signs and ensuring your safety throughout the entire experience. The environment is clinical in its standards and residential in its feel — because healing happens best when you feel safe.
Getting Started with Spravato Treatment in Spring
You’ve spent too long struggling with depression that won’t respond to the medications designed for the majority. Spravato was designed for the minority — the one-in-three patients whose brains need a different pharmacological approach entirely. It’s FDA-approved. It’s backed by rigorous clinical trials. And for many patients, it’s covered by insurance.
Taking the first step is simple. Call us at (713) 772-5315 for your free, no-obligation phone consultation. During this conversation, we’ll answer all your questions, discuss your treatment history, and help you understand whether Spravato treatment is right for you. There’s no pressure, no charge, and everything remains completely confidential.
With three convenient locations across Houston and hours from 6am to 9pm every day of the week, we make it easy to get the care you need when you need it. Dr. Ho and our entire team are here to support you through every step of your healing journey.
Monday-Sunday, 6am-9pm
Free consultation
Insurance assistance
Three Houston locations
REMS-certified provider
Commonly Asked Questions
Get Help NowHow quickly does Spravato therapy work?
Many patients notice improvements within hours or days of their first treatment. The TRANSFORM-2 study showed significant improvement compared to placebo within 24 hours. This rapid action is one of Spravato’s most remarkable qualities, especially compared to traditional antidepressants that can take 4 to 8 weeks to work.
Is Spravato therapy safe?
Yes, when administered by trained medical professionals in a REMS-certified setting. Spravato underwent extensive clinical trials before FDA approval. Common side effects like dissociation, dizziness, and temporary blood pressure increases typically resolve within 1-2 hours. We monitor your vital signs throughout treatment to ensure your safety.
How many treatments will I need?
During the first month, you’ll receive Spravato twice weekly. In the second month, treatment typically decreases to once weekly. After that, most patients continue with maintenance treatments once weekly or every two weeks. The exact frequency depends on your individual response. We’ll work with you to find the schedule that keeps you feeling your best.
What does Spravato treatment feel like?
Experiences vary from person to person. Many patients describe feeling relaxed, calm, or somewhat disconnected from their surroundings. Some people experience mild visual or sensory changes. These effects are temporary and typically resolve within 1-2 hours after treatment ends. Most patients find the experience manageable and therapeutic.
Can I drive after a Spravato treatment?
No, you cannot drive yourself home after Spravato treatment, and you should not drive until the next day after a restful night’s sleep. You’ll need to arrange transportation both to and from your appointment. By the time you leave our facility after the 2-hour observation period, you’ll feel much clearer, but driving remains unsafe until the following day.
Will my insurance cover Spravato?
Many insurance plans cover Spravato for qualifying patients since it’s FDA-approved for treatment-resistant depression. Coverage varies by plan and typically requires prior authorization. Our team handles the insurance process for you, including benefits verification and prior authorization submissions.
Can I continue my current medications?
Spravato is always used alongside an oral antidepressant, so you’ll continue taking your prescribed antidepressant medication. We’ll coordinate with your prescribing physician to ensure your overall treatment plan is optimized. Some medications may require adjustment before starting Spravato, which we’ll discuss during your consultation.
Do I need a referral from my doctor?
No, you don’t need a referral to begin Spravato therapy at Catalyst Health & Wellness. However, coordination with your current prescribing physician is important since Spravato must be used alongside an oral antidepressant. We encourage communication between all members of your healthcare team.
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