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Ketamine Therapy In Spring

Spring, TX Ketamine Therapy Clinic: Advanced Treatment for Depression, Anxiety, PTSD, and Chronic Pain

Physician-led ketamine therapy delivering measurable results — often within hours, not months. Board-certified anesthesiologist Dr. Ho brings decades of expertise to every treatment. Three convenient Houston-area locations, all a short drive from Spring, TX. Open 6am–9pm, seven days a week.

Ketamine Therapy Clinic Near Spring, TX

Maybe you’ve been cycling through medications for years — each one bringing its own side effects, its own adjustment period, its own version of “give it a few more weeks.” At some point, the disappointment stops surprising you.

That cycle doesn’t define your future. Ketamine therapy takes a fundamentally different approach, engaging the glutamate system — the brain’s primary communication highway — to trigger rapid growth of new neural connections in regions weakened by chronic illness. For Spring, TX residents seeking a ketamine therapy clinic with genuine medical expertise, Catalyst Health & Wellness operates three Houston-area locations within easy driving distance. Dr. Ho, our medical director, holds dual board certifications in anesthesiology and pediatrics — a rare combination built for precision ketamine administration, expert monitoring, and putting anxious patients at ease.

Understanding Ketamine Therapy

Ketamine earned FDA approval as an anesthetic in 1970, and hospitals, battlefield medics, and emergency departments worldwide have relied on it for over five decades — making its safety profile one of the most extensively documented in medicine.

The story shifted dramatically in the early 2000s. NIH researchers gave a single sub-anesthetic dose to patients whose depression hadn’t responded to anything — and symptoms lifted within hours. So what makes ketamine different from every antidepressant you’ve already tried? SSRIs, SNRIs, and tricyclics all adjust serotonin, norepinephrine, or dopamine, then ask you to wait weeks. For roughly one-third of depression patients, that approach never works. Ketamine sidesteps those pathways entirely, targeting NMDA receptors within the glutamate network — the brain’s largest neurotransmitter system. This triggers rapid increases in brain-derived neurotrophic factor (BDNF) and measurable new synapse formation. According to the Mayo Clinic, this mechanism represents a genuine breakthrough for treatment-resistant depression.

Put simply: where conventional medications try to patch a leaking pipe, ketamine helps rebuild the plumbing.

This isn't speculative science. The clinical evidence is substantial:

A landmark controlled trial found that ketamine produced a 64% response rate in treatment-resistant depression within just 24 hours, compared to 28% for the active placebo — a number needed to treat of only 2.8 (Murrough et al., 2013)

Repeated infusion protocols have demonstrated response rates approaching 71%, with median time to relapse of 18 days after the final treatment

Neuroimaging studies confirm that ketamine rapidly increases both the density and strength of synaptic connections in the prefrontal cortex — the brain region most damaged by prolonged depression

What Our Patients Say

“Catalyst Ketamine changed everything. Within two sessions, I felt a lifting of the heavy fog that had consumed me for so long.”


"It was by chance I came across Dr. Ho. I have had 4 infusions of ketamine with him. It has been a wonderful experience. Dr. Ho is very accommodating."


"Dr Ho’s 30 years experience is apparent. He skillfully discusses the entire treatment process and applies the correct dosage to ensure optimal patient comfort."


"Dr. Ho’s empathy and experience make all the difference—this is a place where you truly feel safe. Ketamine therapy might sound intimidating, but it’s backed by science."


"This treatment has literally saved my life. I’ve suffered from depression and anxiety for over a decade." 


"This was a life changing experience for me. Dr. Ho is kind and makes you feel really comfortable- you can tell he cares about his patients."


Take the First Step Toward Healing

Schedule

Mon – Sun: 6am-9pm

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Ketamine Delivery Methods at Our Clinic

Catalyst Health & Wellness provides two established ketamine administration routes. Your clinical team will help determine which method suits your medical profile and personal preferences best.

iv ketamine therapy houston tx

IV Ketamine Therapy

With intravenous delivery, ketamine flows directly into your bloodstream through a small catheter. This approach gives your treatment team granular control over the infusion rate — they can adjust the dose in real time based on how you're responding minute by minute. Sessions generally last 40 to 60 minutes for mood-related conditions. IV ketamine produces the most stable and predictable blood concentrations, which is why many specialists consider it the benchmark for ketamine administration.

im ketamine therapy houston tx

IM Ketamine Therapy

Intramuscular ketamine involves a quick injection — typically in the deltoid or thigh — with no IV line required. The medication absorbs rapidly into your system and delivers the same fundamental neuroplastic benefits as the intravenous route. Many patients prefer IM for its simplicity: no catheter, no tubing, and a slightly faster start to the session. You'll still receive full medical monitoring in a private treatment room throughout. Both delivery methods produce strong, well-documented clinical outcomes. Which one is right for you depends on factors we'll discuss together during your consultation.

Conditions We Treat with Ketamine Therapy

Ketamine’s unique ability to promote rapid neural repair makes it effective across a surprisingly broad spectrum of conditions — each of which involves some form of disrupted brain circuitry that traditional treatments often can’t reach.

Because these conditions share overlapping neural dysfunction, ketamine's broad mechanism of action can address multiple symptoms simultaneously. Your treatment plan will be shaped around your specific diagnoses, symptom severity, and personal objectives.

What Your Ketamine Therapy Journey Looks Like

We designed every step of this process with one priority: making sure you feel informed, comfortable, and genuinely cared for from start to finish.

One call is all it takes to get started. No paperwork, no insurance hoops, no referral needed — just an open, honest conversation with someone who understands where you’ve been and what you’re hoping for.

During this call, we’ll cover:

  • Your current symptoms and what treatments you’ve already explored
  • How ketamine therapy works and whether your situation is a good fit
  • A clear walkthrough of what happens during a treatment session
  • Scheduling, pricing, and logistical details
  • Any questions or worries — nothing is off the table

This consultation is completely free and carries zero obligation. It’s your chance to gather information and decide at your own pace.

Once you decide to move forward, we’ll send you a straightforward medical history form. This goes beyond checking boxes — we want to understand your full picture: what medications you’ve taken, what’s worked even partially, what made things worse, and how your symptoms affect your daily life. If you’re comfortable with it, we’ll also reach out to your current doctor or therapist to coordinate care. None of this is required, but it helps us build a treatment plan that’s tailored to you from day one.

Getting ready for your appointment is uncomplicated:

  • Don’t eat for at least 6 hours beforehand
  • Small sips of clear liquids are fine up to 2 hours before
  • Dress in whatever feels comfortable and relaxed

When you walk in:

  • We’ll answer any last-minute questions still on your mind
  • Take your vital signs as a baseline
  • Set up your IV (for IV ketamine) or prepare your injection site (for IM)

Dr. Ho selects the smallest gauge IV needles available. His years as a pediatrician made him exceptionally good at gentle needle placement — a skill that adult patients appreciate just as much. If you’re needle-sensitive, we can apply a topical numbing agent beforehand. For patients with difficult veins, Dr. Ho uses ultrasound guidance to get the placement right on the first try.

You’ll sink into a padded recliner inside your own private treatment room. We lower the lights and set the atmosphere to whatever helps you feel most at ease.

Everything you need is within reach:

  • Noise-cancelling headphones
  • Curated playlists of calming music
  • A lightproof eye mask
  • A warm blanket
  • Lighting you can adjust to your preference

How long your session lasts depends on what we’re treating:

  • Mood disorders (depression, anxiety, PTSD, OCD): approximately 40 minutes of treatment followed by 20 minutes of recovery
  • Chronic pain conditions (fibromyalgia, migraines, EDS, complex pain): approximately 4 hours of treatment followed by 2 hours of recovery

The longer protocol for chronic pain allows us to fully engage the complex central pain pathways involved in conditions like fibromyalgia, migraine headaches, and Ehlers-Danlos Syndrome.

Throughout the entire session, we monitor your blood pressure, heart rate, and oxygen levels at regular intervals. Dr. Ho or a member of our clinical team will either be right there in the room with you or stationed just outside the door, checking in frequently. Feeling nervous before your first treatment is completely normal — nearly everyone does. But by the time that first session wraps up, most patients describe the experience as surprisingly peaceful, safe, and even rejuvenating.

Once your treatment winds down, you’ll rest in our comfortable recovery space until the effects settle and you feel steady again. Most patients describe a gradual return to clarity over 20 to 60 minutes, depending on the treatment type.

A few important things to keep in mind afterward:

  • You absolutely cannot drive yourself home — please arrange your ride before arriving
  • Spend the rest of the day with a trusted friend or family member when possible
  • Hold off on major decisions, strenuous physical activity, and operating any heavy equipment
  • We’ll follow up with a phone call later that day or the next morning to check on you

At the doses we administer at Catalyst Health & Wellness, serious complications are exceptionally rare. Still, our team is always reachable if something feels off or you simply have questions after you leave.

Some patients feel a dramatic shift after a single session. Others build steadily toward their breakthrough over several treatments. Neither response is better or worse — they’re just different roads to the same destination.

Here’s what our typical protocol looks like:

  • Initial series: 6 sessions spread across 2 to 3 weeks for mood-related conditions
  • Dose fine-tuning between sessions if your response suggests we should adjust
  • A personalized maintenance schedule shaped entirely by your results — some patients come back every few weeks, others stretch to monthly visits
  • Continuous evaluation at each appointment to make sure your treatment keeps pace with your progress

Because no two patients carry the same history, no two treatment plans should look identical. We monitor, we listen, and we adapt — making sure your ketamine therapy evolves alongside your healing.

Evidence Backing Ketamine Therapy

The scientific case for ketamine has matured well beyond early pilot studies. Today, it rests on a foundation of large-scale randomized controlled trials, neuroimaging data, and real-world clinical outcomes involving thousands of patients.

The NIH’s own landmark trial — the study that ignited global interest — found that 71% of patients with treatment-resistant depression responded to a single ketamine infusion, versus 0% in the placebo arm. No other antidepressant in psychiatric history has produced that kind of contrast in a controlled setting (Zarate et al., 2006).

A subsequent multi-site trial reinforced those results with a more rigorous design, using an active placebo (midazolam) rather than saline. Ketamine still outperformed the control significantly, with response rates of 64% versus 28% and antidepressant effects appearing within 24 hours (Murrough et al., 2013).

At the cellular level, research published in Science revealed the mechanism behind these outcomes: ketamine reverses the synaptic damage caused by prolonged stress and depression. A single dose increased both synapse number and signal strength in the prefrontal cortex within one day (Li et al., 2010).

For patients with PTSD — a condition particularly prevalent among military veterans and first responders in the greater Houston and Spring areas — a controlled study from the Icahn School of Medicine found that repeated ketamine infusions produced clinically significant and sustained improvement in PTSD symptoms, with two-thirds of participants meeting response criteria (Feder et al., 2014).

Mental health challenges affect communities across Harris County at rates that mirror or exceed national averages. Harris County Public Health identifies behavioral health as a critical priority for the region, underscoring the need for accessible, effective treatment options — particularly for residents in communities like Spring, The Woodlands, Tomball, and Cypress who may face longer travel times to reach specialized care.

What the research consistently shows:

  • Ketamine acts through a completely different biological pathway than any conventional antidepressant — the glutamate system rather than serotonin or dopamine
  • Response rates for treatment-resistant depression cluster around 60-70%, dramatically outperforming traditional medication switches
  • Measurable neuroplastic changes — new synapse formation in mood-regulating brain regions — occur within hours, not weeks
  • The mechanism is broadly effective across diagnoses: depression, anxiety, PTSD, OCD, chronic pain, and suicidal ideation all share overlapping neural circuit dysfunction that ketamine addresses

Why Spring Residents Choose Catalyst as Their Ketamine Therapy Clinic

01

Medical Precision You Can Trust

Ketamine therapy demands a specific skill set — one that sits squarely at the intersection of anesthesiology and psychiatry. Dr. Ho brings both. His board certification in anesthesiology means he's spent his entire career perfecting IV management, real-time dosing adjustments, and physiological monitoring. His pediatric training added a dimension that patients consistently notice: an instinct for gentleness, patience, and putting anxious people at ease. He uses the smallest available IV needles, offers numbing agents proactively, and keeps ultrasound equipment on hand for patients with challenging vein access.

02

Individualized Treatment From Day One

Cookie-cutter protocols don’t cut it when you’re dealing with conditions that have already resisted standard care. Before your first session, we build a complete picture — your medication history, current symptoms, physical health, sleep patterns, stress load, and personal goals. Your treatment plan reflects all of it. And as we learn how you respond, we adjust. Nothing stays static; everything evolves with you.

03

Three Locations, All Close to Spring

Catalyst operates clinics in the Heights, Southwest Houston, and the South Loop — putting at least one location within a manageable drive from Spring, The Woodlands, Tomball, Cypress, and surrounding communities. Every location maintains the same clinical standards, the same extended hours, and the same treatment team quality.

  • Catalyst Health & Wellness Heights 104 W. 12th Street, Suite B, Houston, TX 77008
  • Catalyst Health & Wellness Southwest 7710 Beechnut, Suite 206, Houston, TX 77074
  • Catalyst Health & Wellness South Loop 6300 West Loop S, Suite 526, Bellaire, TX 77401

04

Multiple Treatment Modalities Under One Roof

Ketamine therapy is powerful on its own. But sometimes the strongest outcomes come from combining it with a complementary approach. Because Catalyst also provides Spravato, TMS therapy, and stellate ganglion block, we can build multi-layered treatment strategies without referring you elsewhere. One team, one location, one coordinated plan.

TMS Therapy

Non-invasive magnetic brain stimulation for depression and OCD

Spravato Treatment

FDA-approved nasal esketamine, potentially covered by insurance

Stellate Ganglion Block

Targeted nerve block for PTSD, anxiety, and chronic pain

Beyond IV and IM ketamine, we offer additional innovative treatments that can complement your ketamine therapy:

05

Hours Built Around Your Schedule

All three clinics open at 6am and close at 9pm, Monday through Sunday. Before-work sessions, after-dinner appointments, weekend visits — it all works. We built our schedule around the reality that people seeking treatment are also juggling jobs, families, commutes, and the hundred other demands that don’t pause just because you’re in pain.

Start Ketamine Therapy Near Spring, TX Today

You’ve already done the hardest part — surviving conditions that most people can’t even imagine living with. The medications that were supposed to help didn’t. The wait-and-see approach ran its course. What you haven’t tried yet is a treatment that works through an entirely different mechanism in your brain — one that reaches the biological source of your symptoms instead of skimming the surface.

Your next move is a single phone call. Reach us at (713) 772-5315 and we’ll walk you through everything: how ketamine therapy works, what your first appointment looks like, and whether your situation lines up with what ketamine does best. The call is free, unhurried, and completely confidential.

Three clinics near Spring, TX. Open 7 days a week, 6am to 9pm. A medical team that chose this specialty because they refuse to accept “nothing else works” as a final answer.

Our Schedule

Monday-Sunday, 6am-9pm

Free consultation

Personalized care

Three Houston locations

Expert medical team

Commonly Asked Questions

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How fast does ketamine start working?

Many patients notice improvements within hours of their first treatment, though some people need a few sessions before experiencing the full benefit. This rapid action is one of ketamine’s most remarkable qualities, especially compared to traditional antidepressants that can take 4 to 8 weeks to work.

Is it safe to undergo ketamine therapy?

Yes, when administered by trained medical professionals in a controlled setting. Ketamine has been used safely as an FDA-approved anesthetic for over 50 years. Dr. Ho’s expertise as an anesthesiologist ensures the highest safety standards. We monitor your vital signs throughout treatment, and serious complications are rare.

What does a full ketamine treatment plan involve?

Most patients receive an initial series of six treatments over two to three weeks. After that, you’ll likely need maintenance treatments to sustain your improvements. The frequency varies based on individual response. Some people return every few weeks, while others maintain their benefits with monthly treatments. We’ll work with you to find the schedule that keeps you feeling your best.

What should I expect to feel during a ketamine session?

Experiences vary from person to person. Many patients describe feeling relaxed, peaceful, or slightly disconnected from their surroundings. Some people have visual or sensory experiences, while others simply feel calm. These effects are temporary and subside as the ketamine wears off. Most patients find the experience pleasant and therapeutic.

Will I need someone to take me home after treatment?

No, you cannot drive yourself home after ketamine treatment. You’ll need to arrange transportation. By the time you leave our facility, you’ll feel much clearer, but for your safety, you should not drive, operate heavy machinery, or make important decisions for the rest of the day.

How long can I expect the benefits to last?

This varies considerably between individuals. Some people maintain their improvement for weeks or even months after their initial series. Others need more frequent maintenance treatments. During your follow-up appointments, we’ll assess how you’re responding and adjust your maintenance schedule accordingly.

Can I stay on my current prescriptions while doing ketamine therapy?

In most cases, yes. Ketamine typically works well alongside other psychiatric medications. However, we’ll review your complete medication list during your consultation to ensure there are no contraindications. Never stop taking prescribed medications without consulting your prescribing physician.

Is a doctor's referral required to get started?

No, you don’t need a referral to begin ketamine therapy at Catalyst Health & Wellness. However, communication with your current healthcare providers can be helpful, and we encourage coordination of care whenever possible.

Our Locations

Catalyst Health & Wellness Heights

104 W. 12th Street, Suite B Houston, TX 77008

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Catalyst Health & Wellness Southwest

7710 Beechnut, Suite 206 Houston, TX 77074

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Catalyst Health & Wellness South Loop

6300 West Loop S Suite 525
Bellaire, TX 77401

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Our mission is to empower individuals to overcome life’s challenges through professional psychological support.

Schedule

Mon – Sun: 6am-9pm